The second week of Round of 16 matchups in UEFA Champions League soccer betting action is set for kickoff on Tuesday (Noon Eastern), as headliners Real Madrid hit the road for the first leg of their quarterfinal series against CSKA Moscow at Luzhniki Stadium.

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The runaway leaders of the Spanish La Liga are listed as massive -250 favorites on the soccer betting odds to open their Round of 16 series with a road victory over the underdog Russian side (+700) with draw odds of +330. The Whites won Group D with the most impressive record in Group Stage play, winning all six fixtures and giving up just two goals against while scoring 19.

Real Madrid (11/4 odds to win the Champions League) is also coming off a 4-0 victory over Racing Santander on Saturday in league play that was constructed on a pair of goals by Karim Benzemaand one each from Cristiano Ronaldo and Angel Di Maria. Di Maria suffered a leg injury during that match, however, and will not be available for Tuesday’s Champions League fixture against CSKA Moscow (250/1 odds).

Also Tuesday, Premier League side Chelsea will take on Napoli with kickoff scheduled for 2:45 pm (Eastern) at San Paolo. Napoli (40/1 odds to win the Champions League) is listed at +135 odds to earn the victory over visiting Chelsea (14/1 odds), which is the underdog for their first matchup at +190 odds.

There are also a pair of games on Wednesday, with FC Bayern Munchen at -200 to win on the road at FC Basel (2:45 pm Eastern, St Jakob Park) which is at +550, and Internazionale a +250 road dog at Olympique Marseille (2:45 pm Eastern, Stade Velodrome) which is at +110.

Find international soccer betting odds at Bovada today.